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As the name indicates, denormalization is the reverse process of normalization. It's the controlled introduction of redundancy in to the database design. It helps improve the query performance as the number of joins could be reduced.
Check out the article Q100139 from Microsoft knowledge base and of course, there's much more information available in the net. It'll be a good idea to get a hold of any RDBMS fundamentals text book, especially the one by C. J. Date. Most of the times, it will be okay if you can explain till third normal form.
This is a very open ended question and there could be a lot of reasons behind the poor performance of a query. But some general issues that you could talk about would be: No indexes, table scans, missing or out of date statistics, blocking, excess recompilations of stored procedures, procedures and triggers without SET NOCOUNT ON, poorly written query with unnecessarily complicated joins, too much normalization, excess usage of cursors and temporary tables. Some of the tools/ways that help you troubleshooting performance problems are: SET SHOWPLAN_ALL ON, SET SHOWPLAN_TEXT ON, SET STATISTICS IO ON, SQL Server Profiler, Windows NT /2000 Performance monitor, Graphical execution plan in Query Analyzer.
Indexes in SQL Server are similar to the indexes in books. They help SQL Server retrieve the data quicker. Indexes are of two types. Clustered indexes and non-clustered indexes. When you create a clustered index on a table, all the rows in the table are stored in the order of the clustered index key. So, there can be only one clustered index per table. Non-clustered indexes have their own storage separate from the table data storage. Non-clustered indexes are stored as B-tree structures (so do clustered indexes), with the leaf level nodes having the index key and it's row locater. The row located could be the RID or the Clustered index key, depending up on the absence or presence of clustered index on the table. If you create an index on each column of a table, it improves the query performance, as the query optimizer can choose from all the existing indexes to come up with an efficient execution plan. At the same t ime, data modification operations (such as INSERT, UPDATE, DELETE) will become slow, as every time data changes in the table, all the indexes need to be updated. Another disadvantage is that, indexes need disk space, the more indexes you have, more disk space is used.